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האיגוד הישראלי לכירורגיה פלסטית ואסתטית
Israel Society of Plastic Surgeons

יו"ר האיגוד:

פרופ' יוסף חייק

מזכיר:

ד"ר אריאל טיסונה

גזבר:

ד"ר נמרוד פרידמן

על האיגוד על האיגוד
פרסומי האיגוד פרסומי האיגוד
- ניירות עמדה
- טופסי הסכמה
כנס האיגוד כנס האיגוד
- כנס האיגוד 2024
מתחם המתמחים מתחם המתמחים
מקרים קלינים מקרים קלינים
- מידע רפואי על ניתוחים בתחום הפלסטיקה
- תמונות

Inhibition of Notch Intracellular Domain Suppresses Cell Activation and Fibrotic Factors Production in Hypertrophic Scar Fibroblasts Versus Normal Skin Fibroblasts

בשל "הגנת זכויות יוצרים" מובא להלן קישור לתקציר המאמר. לקריאתו בטקסט מלא, אנא פנה/י לספרייה הרפואית הזמינה לך.

Hypertrophic scar (HS) is the most common complication after skin injury with unknown etiopathogenesis.

There is increasing evidence to suggest that aberrant Notch signaling contributes directly to skin pathogenesis and altered expression of the Notch intracellular domain (NICD) identified in HS.

Therefore, the aim of this study was to investigate the effects of Notch signaling pathway in HS pathogenesis.

Hypertrophic scar and normal skin samples were collected. Notch intracellular domain expression was detected by immunohistochemistry staining and fibroblasts were separated from the samples.

We compared fibrotic factors production, cell viability, migration and apoptosis of HS fibroblasts (HFB) versus normal skin fibroblasts (NFB) by real time quantitative polymerase chain reaction, MTS, cell scratch assay and flow cytometry respectively under the impact of inhibition of Notch signaling by NICD-small-interfering RNA (SiRNA).

הבהרה משפטית: כל מידע המופיע באתר זה נועד להשכלה בלבד ואין לראות בו ייעוץ רפואי או משפטי. אין הר"י אחראית לתוכן המתפרסם באתר זה ולכל נזק שעלול להיגרם.
כל הזכויות על המידע באתר שייכות להסתדרות הרפואית בישראל. מדיניות פרטיות

המערכת פותחה על ידי חברת SLATECH

ברוכים הבאים לאיגוד ישראלי לכירורגיה פלסטית ואסתטית

חברי האיגוד מוזמנים להתעדכן בפעילות האיגוד, לעקוב אחר יומן האירועים, לשלם דמי חבר ועוד

כניסה לחברי האיגוד

זכור אותי בפעם הבאה

הציבור מוזמן לקרוא מידע עדכני ואמין בתחום כירורגיה פלסטית ואסתטית, להוריד טופסי הסכמה ועוד

איני חבר/ת איגוד

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