בשל "הגנת זכויות יוצרים" מובא להלן קישור לתקציר המאמר. לקריאתו בטקסט מלא, אנא פנה/י לספרייה הרפואית הזמינה לך.

Cosmetic films and patches are interesting forms to promote skin penetration of active ingredients as they ensure their long stay of the treated zone of the skin.

Nevertheless, currently developed films and patches are most of all hydrophilic and are not adapted to the hydrophobic molecules.

The aim of this study was to establish if nanodispersion of fatty‐acid based active cosmetic ingredients (ACI) could be a manner to introduce high concentrations of those ACI in hydrophilic films.

Punica granatum seed oil hydroxyphenethyl ester (PHE) is a lipolytic agent obtained by enzymatic conjugation of tyrosol to long chain fatty acids and to enhance its skin diffusion.

Nanodispersions of PHE were prepared by a green emulsion‐solvent evaporation process and dispersed in polyvinyl alcohol films.

Raman imaging coupled to multivariate analysis was used to study the distribution of PHE in the films.Results

In 16 trials (n=1516), the administration of i.v. lidocaine compared with placebo or no treatment led to large reductions in post-extubation cough (risk ratio [RR]: 0.64; 95% confidence interval [CI]: 0.48–0.86)